Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 28 (4), 647-66

Advances in Perioperative Pain Management: Use of Medications With Dual Analgesic Mechanisms, Tramadol & Tapentadol

Affiliations
Review

Advances in Perioperative Pain Management: Use of Medications With Dual Analgesic Mechanisms, Tramadol & Tapentadol

Vaughn E Nossaman et al. Anesthesiol Clin.

Abstract

Recovery from ambulatory surgical procedures can be limited by postoperative pain. Inadequate analgesia may delay or prevent patient discharge and can result in readmission. More frequently, postoperative pain produces discomfort and interrupts sleep, contributing to postoperative fatigue. The development of effective analgesic regimens for the management of postoperative pain is a priority especially in patients with impaired cardiorespiratory, hepatic, or renal function. Tramadol and tapentadol hydrochloride are novel in that their analgesic actions occur at multiple sites. Both agents are reported to be mu-opioid receptor agonists and monoamine-reuptake inhibitors. In contrast to pure opioid agonists, both drugs are believed to have lower risks of respiratory depression, tolerance, and dependence. The Food and Drug Administration has approved both drugs for the treatment of moderate-to-severe acute pain in adults. This article provides an evidence-based account of the role of tramadol and tapentadol in modern clinical practice.

Similar articles

See all similar articles

Cited by 11 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback