Cancer genomes evolve by pulverizing single chromosomes

Cell. 2011 Jan 7;144(1):9-10. doi: 10.1016/j.cell.2010.12.025.


A report in this issue describes "chromothripsis," a new mechanism for genetic instability in cancer cells. Chromothripsis appears to be a cataclysmic event in which a single chromosome is fragmented and then reassembled. The phenomenon raises important questions of how chromosome rearrangements can be confined to defined genome segments.

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