Autologous skin fibroblast and keratinocyte grafts in the treatment of chronic foot ulcers in aging type 2 diabetic patients

J Am Podiatr Med Assoc. 2011 Jan-Feb;101(1):55-8. doi: 10.7547/1010055.


Background: we assessed the tolerability and efficacy of autologous skin cell grafts in older type 2 diabetic patients with chronic foot ulcers.

Methods: treatment with Hyalograft 3D and Laserskin Autograft was proposed to a consecutive series of type 2 diabetic patients older than 65 years affected by long-standing (>6 months) foot ulcers with an area greater than 15 cm(2). Ulcer healing rates and measurements of ulcer area were determined monthly for 12 months.

Results: seven patients with 12 ulcers, nine of which received the described treatment, were enrolled. During 12-month follow-up, all of the ulcers healed except one. In the remaining eight ulcers, the median healing time was 21 weeks (interquartile range, 4-29 weeks).

Conclusions: autologous skin cell grafts are feasible, well tolerated, and apparently effective in the treatment of diabetic ulcers of the lower limbs in advanced age. Age did not seem to moderate healing times.

Publication types

  • Clinical Trial

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Diabetes Mellitus, Type 2 / complications*
  • Female
  • Fibroblasts / transplantation*
  • Foot Ulcer / etiology
  • Foot Ulcer / pathology
  • Foot Ulcer / surgery*
  • Humans
  • Keratinocytes / transplantation*
  • Male
  • Skin Transplantation*
  • Treatment Outcome