Management of uncommon chemotherapy-induced emergencies

Lancet Oncol. 2011 Aug;12(8):806-14. doi: 10.1016/S1470-2045(10)70208-4. Epub 2011 Jan 26.


Chemotherapy can induce various clinical emergencies. Prompt recognition and management of these adverse events are important for avoiding further morbidity and mortality. Some events such as hypersensitivity and extravasation are quite common, whereas emergencies such as neutropenic typhlitis, pancreatitis, and acute haemolysis are very rare. Little information exists on the management of rare chemotherapy-induced emergencies that affect fewer than 1% of patients. We review these uncommon chemotherapy-induced life-threatening emergencies, their pathogenesis and management, and recommendations for rechallenge with the offending chemotherapy.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Drug-Related Side Effects and Adverse Reactions / etiology
  • Drug-Related Side Effects and Adverse Reactions / therapy*
  • Emergencies
  • Humans
  • Neoplasms / drug therapy*


  • Antineoplastic Agents