SirT1 brings stemness closer to cancer and aging

Aging (Albany NY). 2011 Feb;3(2):162-7. doi: 10.18632/aging.100272.


Sirtuin 1 acts in various cell processes, deacetylating both chromatin and non-histone proteins, and its role in cancer and aging has long been studied and debated. Here we discuss another aspect of SirT1 biology, its function as a stem cell pluripotency and differentiation regulator. We evaluate the implications of these findings in sirtuin inhibition-based cancer treatment and in the application of sirtuin activation for anti-aging therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology*
  • Animals
  • Cell Differentiation / physiology
  • Cellular Senescence / physiology
  • Gene Expression Regulation, Developmental
  • Humans
  • Neoplasms / physiopathology*
  • Sirtuin 1 / metabolism*
  • Stem Cells / physiology


  • Sirtuin 1