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. 2011 Feb;69(2):292-302.
doi: 10.1002/ana.22366.

Diagnostic Criteria for Multiple Sclerosis: 2010 Revisions to the McDonald Criteria

Free PMC article

Diagnostic Criteria for Multiple Sclerosis: 2010 Revisions to the McDonald Criteria

Chris H Polman et al. Ann Neurol. .
Free PMC article


New evidence and consensus has led to further revision of the McDonald Criteria for diagnosis of multiple sclerosis. The use of imaging for demonstration of dissemination of central nervous system lesions in space and time has been simplified, and in some circumstances dissemination in space and time can be established by a single scan. These revisions simplify the Criteria, preserve their diagnostic sensitivity and specificity, address their applicability across populations, and may allow earlier diagnosis and more uniform and widespread use.

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