Density of CD163+ CD11c+ dendritic cells increases and CD103+ dendritic cells decreases in the coeliac lesion

Scand J Immunol. 2011 Aug;74(2):186-94. doi: 10.1111/j.1365-3083.2011.02549.x.


Coeliac disease is a chronic inflammation of the intestinal mucosa controlled by gluten-specific T cells restricted by disease-associated HLA-DQ molecules. We have previously reported that mucosal CD11c(+) dendritic cells (DCs) are responsible for activation of gluten-reactive T cells within the coeliac lesion. In mice, intestinal CD11c(+) DCs comprise several functionally distinct subsets. Here, we report that HLA-DQ(+) antigen-presenting cells (APCs) in normal human duodenal mucosa can be divided into four subsets with striking similarities to those described in mice: CD163(+) CD11c(-) macrophages (74%), and CD11c(+) cells expressing either CD163 (7%), CD103 (11%) or CD1c (13%). CD103(+) and CD1c(+) DCs belonged to partly overlapping populations, whereas CD163(+) CD11c(+) APCs appeared to be a distinct population. In the coeliac lesion, we found increased density of CD163(+) CD11c(+) APCs, whereas the density of CD103(+) and CD1c(+) DCs was decreased, suggesting that distinct subpopulations of APCs in coeliac disease may exert different functions in the pathogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antigens, CD / immunology*
  • Antigens, Differentiation, Myelomonocytic / immunology*
  • CD11c Antigen / immunology*
  • Celiac Disease / immunology*
  • Celiac Disease / pathology
  • Cell Count
  • Dendritic Cells / immunology*
  • Duodenum / immunology
  • Duodenum / pathology
  • Female
  • HLA-DQ Antigens / immunology*
  • Humans
  • Integrin alpha Chains / immunology*
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / pathology
  • Macrophages / immunology
  • Male
  • Middle Aged
  • Receptors, Cell Surface / immunology*
  • Young Adult


  • Antigens, CD
  • Antigens, Differentiation, Myelomonocytic
  • CD11c Antigen
  • CD163 antigen
  • HLA-DQ Antigens
  • Integrin alpha Chains
  • Receptors, Cell Surface
  • alpha E integrins