Pancreatic endocrine tumors

Mod Pathol. 2011 Apr:24 Suppl 2:S66-77. doi: 10.1038/modpathol.2010.127.


The endocrine cells of the pancreas and their related cells throughout the gastrointestinal tract give rise to a variety of tumors that pose a diagnostic challenge. There has been progress in understanding their histogenesis, morphology, immunohistochemistry, molecular biology and classifications. This review will focus on nomenclature/terminology, classification, the role of immunohistochemistry, molecular advances, including genetic predisposition, and potential therapeutic targets to define the role of pathology in the application of prognostic and predictive markers for this disease.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / metabolism
  • Genetic Predisposition to Disease
  • Humans
  • Immunohistochemistry
  • Islets of Langerhans / metabolism
  • Islets of Langerhans / pathology
  • Lymphatic Metastasis
  • Neoplasm Staging
  • Neuroendocrine Tumors / genetics
  • Neuroendocrine Tumors / metabolism
  • Neuroendocrine Tumors / secondary*
  • Pancreatic Neoplasms / genetics
  • Pancreatic Neoplasms / metabolism
  • Pancreatic Neoplasms / pathology*
  • Prognosis
  • Receptors, Somatostatin / metabolism
  • Terminology as Topic


  • Biomarkers, Tumor
  • Receptors, Somatostatin