[Influence of peptides from pineal gland on thymus function at aging]

Adv Gerontol. 2010;23(4):543-6.
[Article in Russian]


The interference between thymus and pineal gland during their involution is considered in this review. The research data about influence of thymus peptides on pineal gland and pineal peptides on thymus is summarized. Analysis of these data showed that pineal peptides (epithalamin, epitalon) had more effective geroprotective effect on thymus involution in comparison with geroprotective effect of thymic peptides (thymalin, thymogen) on involution of pineal gland. The key mechanisms of pineal peptides effect on thymus dystrophy is immunoendocrine cooperation, which is realized as transcription's activation of various proteins.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Adjuvants, Immunologic / metabolism
  • Aging / immunology
  • Aging / metabolism*
  • Animals
  • Endocrine Surgical Procedures / adverse effects
  • Hormone Replacement Therapy
  • Humans
  • Melatonin / metabolism
  • Melatonin / therapeutic use
  • Models, Animal
  • Peptide Hormones / metabolism*
  • Peptide Hormones / therapeutic use
  • Pineal Gland / metabolism*
  • Pineal Gland / surgery
  • Postoperative Complications / etiology
  • Postoperative Complications / therapy
  • Thymus Extracts / therapeutic use
  • Thymus Gland / metabolism*
  • Thymus Gland / surgery


  • Adjuvants, Immunologic
  • Peptide Hormones
  • Thymus Extracts
  • Melatonin