MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11

FEBS Lett. 2011 May 6;585(9):1363-7. doi: 10.1016/j.febslet.2011.04.018. Epub 2011 Apr 14.


MicroRNAs are widely dysregulated in various cancers and integrated into tumorigenic programs as either oncogenes or tumor suppressor genes. Here, we show that miR-26b, which is down-regulated in human breast cancer specimens and cell lines, impairs viability and triggers apoptosis of human breast cancer MCF7 cells. SLC7A11 is identified as a direct target of miR-26b and its expression is remarkably increased in both breast cancer cell lines and clinical samples. Furthermore, SLC7A11 silence mimics miR-26b-aroused viability impairment and apoptosis in MCF7 cells. Our studies reveal a protective role of miR-26b in the molecular etiology of human breast cancer by promoting apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amino Acid Transport System y+ / genetics*
  • Amino Acid Transport System y+ / metabolism
  • Apoptosis / genetics*
  • Blotting, Western
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Cell Line, Tumor
  • Cell Survival / genetics
  • Down-Regulation
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs / genetics*
  • Middle Aged
  • Reverse Transcriptase Polymerase Chain Reaction
  • Time Factors


  • Amino Acid Transport System y+
  • MIRN26A microRNA, human
  • MicroRNAs
  • SLC7A11 protein, human