Topical clindamycin 1% vs. linoleic acid-rich phosphatidylcholine and nicotinamide 4% in the treatment of acne: a multicentre-randomized trial

Int J Cosmet Sci. 2011 Oct;33(5):467-76. doi: 10.1111/j.1468-2494.2011.00658.x. Epub 2011 Jun 13.


It has been shown that topical linoleic acid rich-phosphatidylcholine seems to be effective in normalization of follicular hyperkeratinization, whereas nicotinamide has an interesting anti-inflammatory effect. However, little is known about their combined effect on acne. A multicentre, double-blind, 12-week randomized vehicle and parallel-active control study was conducted by clinical and biophysical non-invasive measurements to evaluate the efficacy, tolerability and safety of a 4% nicotinamide-phospholipidic (N-PHCL) emulsion vs. 1% topical clindamycin phosphate applied once daily. Four percentage N-PHCL cosmetic treatment resulted slightly superior to topical clindamycin with all the parameters studied for its better compliance and the global clinical improvement.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Administration, Topical
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Clindamycin / administration & dosage
  • Clindamycin / therapeutic use*
  • Double-Blind Method
  • Humans
  • Linoleic Acid / chemistry*
  • Niacinamide / administration & dosage
  • Niacinamide / chemistry
  • Niacinamide / therapeutic use*
  • Phosphatidylcholines / administration & dosage
  • Phosphatidylcholines / chemistry
  • Phosphatidylcholines / therapeutic use*


  • Anti-Bacterial Agents
  • Phosphatidylcholines
  • Niacinamide
  • Clindamycin
  • Linoleic Acid