Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Sep;72(5):874-80.

Denatured Muscle Grafts for Nerve Repair. An Experimental Model of Nerve Damage in Leprosy

Affiliations
  • PMID: 2170419

Denatured Muscle Grafts for Nerve Repair. An Experimental Model of Nerve Damage in Leprosy

J H Pereira et al. J Bone Joint Surg Br. .

Abstract

About 20% of patients with leprosy develop localised granulomatous lesions in peripheral nerves. We report experiments in guinea-pigs in which freeze-thawed autogenous muscle grafts were used for the treatment of such mycobacterial granulomas. Granulomas were induced in guinea-pig tibial nerves and the animals were left for 7 to 100 days in order to assess maximal damage. The local area of nerve damage was then excised and the gap filled with denatured muscle grafts. Clinical assessment after periods up to 150 days showed good sensory and motor recovery which correlated well with the histological findings. The muscle graft technique may be of value for the treatment of chronic nerve lesions in selected cases of leprosy.

Comment in

  • Muscle grafts for nerve repair.
    Crawford CL, Hobbs MJ. Crawford CL, et al. J Bone Joint Surg Br. 1991 Jul;73(4):696-7. J Bone Joint Surg Br. 1991. PMID: 2071667 No abstract available.

Similar articles

See all similar articles

Publication types

LinkOut - more resources

Feedback