Upper gastrointestinal bleeding in an end-stage renal disease patient treated with fluoxetine

Gen Hosp Psychiatry. 2011 Sep-Oct;33(5):530.e1-3. doi: 10.1016/j.genhosppsych.2011.03.012. Epub 2011 May 20.


The defective platelets of end-stage renal disease patients might be further incapacitated by the antiplatelet effect of selective serotonin reuptake inhibitor, and bleeding tendency in these patients could be aggravated. Here we demonstrate an end-stage renal disease patient who was admitted for duodenal ulcer bleeding during the treatment with fluoxetine, and the bleeding did not stop by various active treatments until the cessation of fluoxetine.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bipolar Disorder / complications*
  • Bipolar Disorder / drug therapy*
  • Duodenal Ulcer*
  • Fluoxetine / adverse effects*
  • Fluoxetine / therapeutic use
  • Gastrointestinal Hemorrhage / chemically induced
  • Humans
  • Kidney Failure, Chronic / complications
  • Male
  • Peptic Ulcer Hemorrhage / chemically induced*
  • Peptic Ulcer Hemorrhage / therapy
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Treatment Outcome


  • Serotonin Uptake Inhibitors
  • Fluoxetine