Amelioratory effect of Andrographis paniculata Nees on liver, kidney, heart, lung and spleen during nicotine induced oxidative stress

Sreeparna Neogy; Subhasis Das; Santanu Kar Mahapatra; Nirjal Mandal; Somenath Roy

doi:10.1016/j.etap.2007.10.034

Amelioratory effect of Andrographis paniculata Nees on liver, kidney, heart, lung and spleen during nicotine induced oxidative stress

Environ Toxicol Pharmacol. 2008 May;25(3):321-8. doi: 10.1016/j.etap.2007.10.034. Epub 2007 Nov 4.

Authors

Sreeparna Neogy¹, Subhasis Das, Santanu Kar Mahapatra, Nirjal Mandal, Somenath Roy

Affiliation

¹ Immunology and Microbiology Laboratory, Department of Human Physiology with Community Health, Vidyasagar University, Midnapore 721102, West Bengal, India.

PMID: 21783869
DOI: 10.1016/j.etap.2007.10.034

Abstract

The ameliorative properties of bioactive compound andrographolide (ANDRO), aqueous extract of Andrographis paniculata (AE-AP) and vitamin E (vit.E) were tested against nicotine induced liver, kidney, heart, lung and spleen toxicity. A group of male Wistar rats were intraperitoneally administered vehicle, nicotine (1mg/kg body weight/day), nicotine+ANDRO (250mg/kg body weight/day), nicotine+AE-AP (250mg/kg body weight/day) and nicotine+vit.E (50mg/kg body weight/day) for the period of 7 days. The significantly increased levels of lipid peroxidation, protein oxidation and the decreased antioxidant enzyme status were noted in nicotine treated group as compared to vehicle treated group. ANDRO, AE-AP and vit.E significantly reduced the lipid peroxidation, protein oxidation and increased the antioxidant enzyme status. This indicates A. paniculata and vit.E may act as putative protective agent against nicotine induced tissue injury and may pave a new path to develop suitable drug therapy.