Breaking the cell cycle of HSCs by p57 and friends

Cell Stem Cell. 2011 Sep 2;9(3):187-92. doi: 10.1016/j.stem.2011.08.005.


The cell cycle regulators involved in maintaining the quiescence, and thereby the self-renewal capacity, of somatic stem cells have long been elusive. Two new Cell Stem Cell articles in this issue (Matsumoto et al., 2011; Zou et al., 2011) now show that the CDK inhibitor p57 is a crucial brake for cycling HSCs, and links self-renewal activity to cell cycle quiescence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Comment

MeSH terms

  • Adult Stem Cells / metabolism*
  • Animals
  • Cell Survival*
  • Cellular Senescence*
  • Cyclin D1 / metabolism*
  • Cyclin-Dependent Kinase Inhibitor p27 / metabolism*
  • Cyclin-Dependent Kinase Inhibitor p57 / metabolism*
  • HSC70 Heat-Shock Proteins / metabolism*
  • Hematopoietic Stem Cells / metabolism*


  • Cdkn1c protein, mouse
  • Cyclin-Dependent Kinase Inhibitor p57
  • HSC70 Heat-Shock Proteins
  • Cyclin D1
  • Cyclin-Dependent Kinase Inhibitor p27