1-Hexyl n-cyanoacrylate compound (Neucrylate™ AN), a new berry aneurysm treatment. I. Theoretical basis and laboratory evaluation

J Neurointerv Surg. 2012 Jan 1;4(1):45-9. doi: 10.1136/jnis.2010.004317. Epub 2011 May 4.


Purpose: To develop and optimize a system for treating cerebral berry aneurysm using a new polymer based liquid embolic agent.

Materials and methods: Using a variety of human corrosion casting aneurysm replicas placed in a circuit of pulsatile flowing blood, techniques were developed to optimize aneurysm filling and recreate good blood flow dynamics. As part of this effort, both experienced physicians and lay personnel were asked to treat these replicas to discover common failure modes. Additional surgically created aneurysms in dog carotid arteries were treated by experienced physicians.

Results: Physicians experienced in the use of microcatheters and endovascular techniques learned to use the device effectively after, on average, five aneurysm treatments. In the dog aneurysms, all were treated to complete filling.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Catheterization / methods*
  • Catheterization / standards
  • Clinical Laboratory Techniques / methods
  • Clinical Laboratory Techniques / standards
  • Corrosion Casting / methods*
  • Corrosion Casting / standards
  • Cyanoacrylates / administration & dosage*
  • Disease Models, Animal
  • Dogs
  • Humans
  • Intracranial Aneurysm / classification
  • Intracranial Aneurysm / pathology
  • Intracranial Aneurysm / surgery*
  • Sheep
  • Swine
  • Tissue Adhesives / administration & dosage*


  • Cyanoacrylates
  • Tissue Adhesives