Stem cells and skin regeneration

Folia Histochem Cytobiol. 2011;49(3):375-80. doi: 10.5603/fhc.2011.0053.


Stem cells represent a great hope for regenerative medicine. In adult life, stem cell deposits are kept in organ niches; the need for tissue or organ regeneration mobilizes stem cells via the SDF-1-CXCR4 regulation axis. Constant regeneration of the skin is achieved due to stem cell differentiation within the epidermis and the hair follicle; thus, skin may serve as an excellent source of stem cells. This is of paramount importance in the treatment of chronic skin wounds and burns.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / metabolism
  • Cell Differentiation / physiology
  • Chemokine CXCL12 / metabolism
  • Epidermal Cells
  • Humans
  • Receptors, CXCR4 / metabolism
  • Regeneration / physiology*
  • Regenerative Medicine
  • Skin / cytology*
  • Skin / injuries
  • Skin / pathology
  • Skin Physiological Phenomena*
  • Stem Cells / cytology
  • Stem Cells / physiology*


  • Biomarkers
  • Chemokine CXCL12
  • Receptors, CXCR4