Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis

Gerodontology. 2012 Jun;29(2):e680-4. doi: 10.1111/j.1741-2358.2011.00544.x. Epub 2011 Nov 30.


Introduction: Denture stomatitis (DS) is the most common form of chronic oral candidiasis. The standard treatment for DS is nystatin, which is accompanied with complications such as a bitter taste. The aim of this study was to compare the effect of garlic with nystatin in DS.

Material and methods: This randomised clinical trial study was performed on 40 patients with DS. After obtaining written consent, patients were divided into two groups while members of each group were given either nystatin or garlic extract for 4 weeks. The length and width of erythema area was measured at the end of the first, second, third, and the fourth weeks using a calliper. Data were analysed by SPSS and statistical tests including variance analysis with anova repeated measures, chi-square, and least square differences.

Results: The changes in the length and width of erythema at different times according to the type of treatment were found to be significant while an accelerated recovery was demonstrated for nystatin (p < 0.001). Both regimens resulted in significant recovery (p < 0.0001). Greater satisfaction with the use of garlic rather than nystatin was mentioned (p < 0.0001).

Conclusion: Considering the efficacy of garlic and lack of side effects for this compound and also regarding the nystatin-associated complications, garlic extract can be introduced as a substitution for standard treatment in DS.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antifungal Agents / adverse effects
  • Antifungal Agents / therapeutic use*
  • Candidiasis, Oral / drug therapy
  • Candidiasis, Oral / pathology
  • Diarrhea / chemically induced
  • Double-Blind Method
  • Erythema / drug therapy
  • Erythema / pathology
  • Female
  • Garlic*
  • Humans
  • Male
  • Mouthwashes / therapeutic use*
  • Nausea / chemically induced
  • Nystatin / adverse effects
  • Nystatin / therapeutic use*
  • Patient Satisfaction
  • Phytotherapy / methods*
  • Plant Extracts / therapeutic use*
  • Stomatitis, Denture / drug therapy*
  • Stomatitis, Denture / pathology
  • Taste Disorders / chemically induced


  • Antifungal Agents
  • Mouthwashes
  • Plant Extracts
  • Nystatin