The impact of plant-pathogen studies on medicinal drug discovery

Chem Soc Rev. 2012 Apr 21;41(8):3168-78. doi: 10.1039/c2cs15301g. Epub 2012 Feb 1.


The pharmaceutical industry is reliant on a constant supply of new chemical entities and molecular targets for disease intervention. In this tutorial review, we want to illustrate that basic research studies on the biological function of natural products involved in plant-pathogen interactions can serve as an inspiring source for the identification of new bioactive entities as well as of strategies on how to achieve small molecule manipulation of biological systems. An application of findings from plant-pathogen interaction studies might therefore display a significant impact on drug discovery.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Products / chemistry
  • Biological Products / pharmacology
  • Biomimetics / methods*
  • Drug Discovery / methods*
  • Host-Pathogen Interactions* / immunology
  • Humans
  • Plant Diseases / immunology
  • Plant Immunity
  • Plants* / immunology
  • Plants* / microbiology
  • Plants* / parasitology
  • Plants* / virology
  • Small Molecule Libraries / chemistry
  • Small Molecule Libraries / pharmacology


  • Biological Products
  • Small Molecule Libraries