As a rare cause of drug-induced cough: topiramate

Acta Neurol Belg. 2012 Jun;112(2):217-20. doi: 10.1007/s13760-012-0016-2. Epub 2012 Feb 3.


The most common causes of chronic cough in nonsmokers are postnasal drip syndrome, asthma, and gastroesophageal reflux disease. Drugs are also important in the etiology of resistant cough. Most common drugs inducing cough are the ACE inhibitors. Many drugs other than ACE inhibitors can also cause dry cough and one among them is topiramate. It is a new generation, efficacy-proved antiepileptic drug that is used widely for migraine prophylaxis in many countries. Most common adverse events of topiramate are paresthesia, cognitive symptoms, fatigue, insomnia, nausea, loss of apetite, anxiety, and dizziness. There is only one case report about topiramate associated cough in the literature. The present report refers to a patient, presenting with cough who is on topiramate treatment for migraine prophylaxis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cough / chemically induced*
  • Female
  • Fructose / adverse effects
  • Fructose / analogs & derivatives*
  • Humans
  • Migraine Disorders / prevention & control
  • Neuroprotective Agents / adverse effects*
  • Topiramate


  • Neuroprotective Agents
  • Topiramate
  • Fructose