Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care

Int J Psychiatry Clin Pract. 2012 Jun;16(2):77-84. doi: 10.3109/13651501.2012.667114. Epub 2012 Apr 30.

Abstract

Objective: Anxiety disorders are frequently under-diagnosed conditions in primary care, although they can be managed effectively by general practitioners.

Methods: This paper is a short and practical summary of the World Federation of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) for the treatment in primary care. The recommendations were developed by a task force of 30 international experts in the field and are based on randomized controlled studies.

Results: First-line pharmacological treatments for these disorders are selective serotonin reuptake inhibitors (for all disorders), serotonin-norepinephrine reuptake inhibitors (for some) and pregabalin (for generalized anxiety disorder only). A combination of medication and cognitive behavior/exposure therapy was shown to be a clinically desired treatment strategy.

Conclusions: This short version of an evidence-based guideline may improve treatment of anxiety disorders, OCD, and PTSD in primary care.

Publication types

  • Practice Guideline
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antidepressive Agents, Tricyclic / therapeutic use
  • Antipsychotic Agents / therapeutic use
  • Anxiety Disorders / drug therapy*
  • Benzodiazepines / therapeutic use
  • Dose-Response Relationship, Drug
  • Histamine Antagonists / therapeutic use
  • Humans
  • Obsessive-Compulsive Disorder / drug therapy*
  • Pregabalin
  • Serotonin Uptake Inhibitors / therapeutic use
  • Stress Disorders, Post-Traumatic / drug therapy*
  • gamma-Aminobutyric Acid / analogs & derivatives
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Antidepressive Agents, Tricyclic
  • Antipsychotic Agents
  • Histamine Antagonists
  • Serotonin Uptake Inhibitors
  • Benzodiazepines
  • Pregabalin
  • gamma-Aminobutyric Acid