Scopararanes C-G: new oxygenated pimarane diterpenes from the marine sediment-derived fungus Eutypella scoparia FS26

Mar Drugs. 2012 Mar;10(3):539-550. doi: 10.3390/md10030539. Epub 2012 Feb 27.


Five new oxygenated pimarane diterpenes, named scopararanes C-G (1-5) were isolated from the culture of a marine sediment-derived fungus Eutypella scoparia FS26 obtained from the South China Sea. The structures of these compounds were established on the basis of extensive spectroscopic analysis. The absolute configurations of compounds 1-5, were determined by CD spectroscopic analysis and comparison with literature data. All isolated compounds (1-5) were evaluated for their cytotoxic activities against MCF-7, NCI-H460, and SF-268 tumor cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) method.

Keywords: pimarane diterpenes; Eutypella scoparia; South China Sea; cytotoxic activity; marine sediment-derived fungus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / isolation & purification*
  • Abietanes / pharmacology
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology
  • Cell Line, Tumor
  • Circular Dichroism
  • Coloring Agents
  • Culture Media / chemistry
  • Drug Screening Assays, Antitumor
  • Fermentation
  • Geologic Sediments / microbiology
  • Humans
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Conformation
  • Seawater / microbiology
  • Spectrometry, Mass, Electrospray Ionization
  • Tetrazolium Salts
  • Thiazoles
  • Xylariales / metabolism*


  • Abietanes
  • Antibiotics, Antineoplastic
  • Coloring Agents
  • Culture Media
  • Tetrazolium Salts
  • Thiazoles
  • thiazolyl blue