What a difference a phosphate makes: life or death decided by a single amino acid in MDM2

Yao-Cheng Li; Geoffrey M Wahl

doi:10.1016/j.ccr.2012.04.033

What a difference a phosphate makes: life or death decided by a single amino acid in MDM2

Cancer Cell. 2012 May 15;21(5):595-596. doi: 10.1016/j.ccr.2012.04.033.

Authors

Yao-Cheng Li¹, Geoffrey M Wahl²

Affiliations

¹ Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92130, USA.
² Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92130, USA. Electronic address: wahl@salk.edu.

PMID: 22624708
DOI: 10.1016/j.ccr.2012.04.033

Abstract

In this issue of Cancer Cell, Gannon and colleagues create genetically engineered mice to test the role phosphorylation plays in the modification of one serine long thought to play a critical role in controlling the activity of MDM2, one of p53's main negative regulators.

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