What a difference a phosphate makes: life or death decided by a single amino acid in MDM2

Cancer Cell. 2012 May 15;21(5):595-6. doi: 10.1016/j.ccr.2012.04.033.

Abstract

In this issue of Cancer Cell, Gannon and colleagues create genetically engineered mice to test the role phosphorylation plays in the modification of one serine long thought to play a critical role in controlling the activity of MDM2, one of p53's main negative regulators.

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