Aspiration biopsy of mammary analogue secretory carcinoma of accessory parotid gland: another diagnostic dilemma in matrix-containing tumors of the salivary glands

Diagn Cytopathol. 2014 Jan;42(1):49-53. doi: 10.1002/dc.22886. Epub 2012 Jul 16.


Mammary analogue secretory carcinoma (MASC) is a newly described rare salivary gland tumor, which shares morphologic features with acinic cell carcinoma, low-grade cystadenocarcinoma, and secretory carcinoma of the breast. This is the first reported case of MASC of an accessory parotid gland detected by aspiration biopsy with radiologic and histologic correlation in a 34-year-old patient. Sonographically-guided aspiration biopsy showed cytologic features mimicking those of low-grade mucoepidermoid carcinoma, including sheets of bland epithelial cells, dissociated histiocytoid cells with intracytoplasmic mucinous material, and spindle cells lying in a web-like matrix. Histologic sections showed a circumscribed tumor with microcystic spaces lined by bland uniform epithelial cells and containing secretory material. The tumor cells expressed mammaglobin and BRST-2. The cytologic features, differential diagnosis, and pitfalls are discussed. The pathologic stage was pT1N0. The patient showed no evidence of disease at 1 year follow-up.

Keywords: aspiration biopsy; mammary analogue secretory carcinoma; mucoepidermoid carcinoma; salivary gland.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biomarkers, Tumor / analysis
  • Biopsy, Needle
  • Breast Neoplasms / chemistry
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / pathology*
  • Carcinoma / chemistry
  • Carcinoma / diagnostic imaging
  • Carcinoma / pathology*
  • Carcinoma, Mucoepidermoid / chemistry
  • Carcinoma, Mucoepidermoid / diagnostic imaging
  • Carcinoma, Mucoepidermoid / pathology*
  • Carcinoma, Mucoepidermoid / surgery
  • Diagnosis, Differential
  • Female
  • Humans
  • Image-Guided Biopsy
  • Keratins / analysis
  • Mammaglobin A
  • Neoplasm Staging
  • Parotid Neoplasms / chemistry
  • Parotid Neoplasms / diagnostic imaging
  • Parotid Neoplasms / pathology*
  • Parotid Neoplasms / surgery
  • Ultrasonography
  • Vimentin / analysis


  • Biomarkers, Tumor
  • Mammaglobin A
  • Vimentin
  • Keratins

Supplementary concepts

  • Secretory breast carcinoma