[Neovascular membrane and pregnancy. Treatment with bevacizumab]

Arch Soc Esp Oftalmol. 2012 Sep;87(9):297-300. doi: 10.1016/j.oftal.2011.09.011. Epub 2012 May 30.
[Article in Spanish]

Abstract

Clinical case: Female in her sixth month of pregnancy, with a history of refractive surgery, who consulted due to a metamorphopsia and decrease in visual acuity in the right eye. A presumed ocular histoplasmosis syndrome (POHS) and a subfoveal choroidal neovascular membrane were observed in the fundoscopy. Two monthly doses of intravitreal bevacizumab were given after the labour, but the third dose was never inyected as the patient became pregnant again. She subsequently had a spontaneous miscarriage.

Discussion: Treatment with intravitreal bevacizumab during pregnancy is controversial as it may increase the risk of miscarriage during the first trimester.

Publication types

  • Case Reports

MeSH terms

  • Abortion, Spontaneous / chemically induced*
  • Adult
  • Angiogenesis Inhibitors / adverse effects
  • Angiogenesis Inhibitors / therapeutic use*
  • Antibodies, Monoclonal, Humanized / adverse effects
  • Antibodies, Monoclonal, Humanized / therapeutic use*
  • Bevacizumab
  • Choroidal Neovascularization / diagnosis
  • Choroidal Neovascularization / drug therapy
  • Choroidal Neovascularization / etiology
  • Contraindications
  • Eye Infections, Fungal / complications*
  • Eye Infections, Fungal / diagnosis
  • Female
  • Histoplasmosis / complications*
  • Histoplasmosis / diagnosis
  • Humans
  • Intravitreal Injections
  • Keratomileusis, Laser In Situ
  • Postoperative Complications
  • Pregnancy
  • Pregnancy Complications / diagnosis*
  • Pregnancy Complications, Infectious / diagnosis
  • Pregnancy Trimester, First
  • Puerperal Disorders / drug therapy*
  • Puerperal Disorders / etiology
  • Tomography, Optical Coherence

Substances

  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab