Polymeric biomaterials for stem cell bioengineering

Marina Prewitz; Friedrich Philipp Seib; Tilo Pompe; Carsten Werner

doi:10.1002/marc.201200382

Polymeric biomaterials for stem cell bioengineering

Macromol Rapid Commun. 2012 Sep 14;33(17):1420-31. doi: 10.1002/marc.201200382. Epub 2012 Aug 7.

Authors

Marina Prewitz¹, Friedrich Philipp Seib, Tilo Pompe, Carsten Werner

Affiliation

¹ Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials, Hohe Straße 6, 01069 Dresden, Germany.

PMID: 22887752
DOI: 10.1002/marc.201200382

Abstract

This review covers the application of polymeric materials in stem cell bioengineering. Main emphasis is directed towards current material design concepts that mimic distinct exogenous signals of the stem cell microenvironment. Progress within the field of stem cell-specific biomaterials will be discussed, focusing on pluripotent, hematopoietic, mesenchymal and neural stem cells. The future role of biomaterials will be outlined with possible applications for cell reprogramming and engineering cancer cell microenvironments.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biopolymers / chemistry*
Cellular Reprogramming
Extracellular Matrix / metabolism
Genetic Engineering
Humans
Stem Cell Niche
Stem Cells / cytology*
Tissue Engineering*

Substances

Biopolymers