Thrombophilia and venous thromboembolism: RIETE experience

Best Pract Res Clin Haematol. 2012 Sep;25(3):285-94. doi: 10.1016/j.beha.2012.07.007. Epub 2012 Aug 17.


RIETE is an ongoing registry of consecutive patients with acute venous thromboembolism (VTE). First we learned that in RIETE the prevalence of positive tests was 32%. One in every 2 patients younger than 50 years tested positive, with no differences between idiopathic or secondary, first event or recurrent VTE. In contrast, one in every 4 patients older than 50 years tested positive. Then, we found that the younger age of women with factor V Leiden or prothrombin G20210A may be attributed to the higher proportion of women who had the VTE during pregnancy or contraceptive use. At variance with this, 60% of men had idiopathic VTE, and only those with factor V Leiden were younger than those who tested negative. We need more patients, more data and a longer follow-up. In a near future we might be able to learn more about the outcome of VTE patients.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Adult
  • Age Factors
  • Contraceptives, Oral / adverse effects
  • Factor V / analysis*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Pregnancy
  • Prothrombin / analysis
  • Prothrombin / genetics
  • Registries*
  • Sex Factors
  • Thrombophilia / complications
  • Thrombophilia / diagnosis*
  • Thrombophilia / etiology
  • Venous Thromboembolism / diagnosis*
  • Venous Thromboembolism / etiology
  • Venous Thromboembolism / pathology


  • Contraceptives, Oral
  • factor V Leiden
  • Factor V
  • Prothrombin