Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors

Dev Cell. 2012 Nov 13;23(5):981-94. doi: 10.1016/j.devcel.2012.10.013.


How dermal papilla (DP) niche cells regulate hair follicle progenitors to control hair growth remains unclear. Using Tbx18(Cre) to target embryonic DP precursors, we ablate the transcription factor Sox2 early and efficiently, resulting in diminished hair shaft outgrowth. We find that DP niche expression of Sox2 controls the migration speed of differentiating hair shaft progenitors. Transcriptional profiling of Sox2 null DPs reveals increased Bmp6 and decreased BMP inhibitor Sostdc1, a direct Sox2 transcriptional target. Subsequently, we identify upregulated BMP signaling in knockout hair shaft progenitors and demonstrate that Bmp6 inhibits cell migration, an effect that can be attenuated by Sostdc1. A shorter and Sox2-negative hair type lacks Sostdc1 in the DP and shows reduced migration and increased BMP activity of hair shaft progenitors. Collectively, our data identify Sox2 as a key regulator of hair growth that controls progenitor migration by fine-tuning BMP-mediated mesenchymal-epithelial crosstalk.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Bone Morphogenetic Protein 6 / metabolism
  • Bone Morphogenetic Proteins / deficiency
  • Bone Morphogenetic Proteins / metabolism*
  • Cell Movement
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism
  • Hair / growth & development*
  • Hair Follicle / cytology
  • Hair Follicle / embryology*
  • Hair Follicle / growth & development
  • Hair Follicle / metabolism*
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • SOXB1 Transcription Factors / deficiency
  • SOXB1 Transcription Factors / genetics
  • SOXB1 Transcription Factors / metabolism*
  • Signal Transduction
  • Transcriptome


  • Adaptor Proteins, Signal Transducing
  • Bmp6 protein, mouse
  • Bone Morphogenetic Protein 6
  • Bone Morphogenetic Proteins
  • SOXB1 Transcription Factors
  • Sostdc1 protein, mouse
  • Sox2 protein, mouse