Functional disability in medication management and driving among individuals with HIV: a 1-year follow-up study

J Clin Exp Neuropsychol. 2013;35(1):49-58. doi: 10.1080/13803395.2012.747596. Epub 2012 Dec 14.

Abstract

Approximately 50% of individuals with HIV report cognitive deficits that can affect social or occupational functioning. The present study used a longitudinal design (1 year) to examine the relationship between cognitive factors and incidental functional deficits in medication management and driving ability among a cohort of 101 HIV+ participants. Participants were classified into groups of functionally "stable" and "disabled" for each laboratory-based functional task (i.e., Medication Management Task-Revised, MMT-R, and PC-based driving simulator). We hypothesized that participants who exhibited a functional deficit in either MMT-R or driving at follow-up assessment would demonstrate significantly poorer baseline cognitive performance at study entry than participants who remained functionally stable. As hypothesized, participants who demonstrated significantly lower baseline performance in learning/memory and executive functioning also demonstrated functional disability on the MMT-R at follow-up when compared to functionally stable participants. Poor baseline performance in speed of information processing was associated with a deficit in driving ability at follow-up assessment. Our results suggest that lower baseline cognitive functioning predicts downstream functional disability, and that deficits in learning/memory and information processing speed are particularly predictive of deficits in medication management and driving ability.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Anti-HIV Agents / adverse effects*
  • Anti-HIV Agents / therapeutic use
  • Automobile Driving / psychology*
  • Cognition Disorders / etiology
  • Cognition Disorders / psychology
  • Data Interpretation, Statistical
  • Disability Evaluation*
  • Disease Management
  • Female
  • Follow-Up Studies
  • HIV Infections / drug therapy*
  • HIV Infections / psychology*
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Psychomotor Performance / drug effects

Substances

  • Anti-HIV Agents