LepChorionDB, a database of Lepidopteran chorion proteins and a set of tools useful for the identification of chorion proteins in Lepidopteran proteomes

Insect Biochem Mol Biol. 2013 Feb;43(2):189-96. doi: 10.1016/j.ibmb.2012.12.001. Epub 2012 Dec 20.


Chorion proteins of Lepidoptera have a tripartite structure, which consists of a central domain and two, more variable, flanking arms. The central domain is highly conserved and it is used for the classification of chorion proteins into two major classes, A and B. Annotated and unreviewed Lepidopteran chorion protein sequences are available in various databases. A database, named LepChorionDB, was constructed by searching 5 different protein databases using class A and B central domain-specific profile Hidden Markov Models (pHMMs), developed in this work. A total of 413 Lepidopteran chorion proteins from 9 moths and 1 butterfly species were retrieved. These data were enriched and organised in order to populate LepChorionDB, the first relational database, available on the web, containing Lepidopteran chorion proteins grouped in A and B classes. LepChorionDB may provide insights in future functional and evolutionary studies of Lepidopteran chorion proteins and thus, it will be a useful tool for the Lepidopteran scientific community and Lepidopteran genome annotators, since it also provides access to the two pHMMs developed in this work, which may be used to discriminate A and B class chorion proteins. LepChorionDB is freely available at http://bioinformatics.biol.uoa.gr/LepChorionDB.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Computational Biology / instrumentation
  • Computational Biology / methods*
  • Databases, Protein*
  • Egg Proteins / chemistry
  • Egg Proteins / genetics*
  • Egg Proteins / metabolism
  • Insect Proteins / chemistry
  • Insect Proteins / genetics*
  • Insect Proteins / metabolism
  • Internet
  • Lepidoptera / chemistry
  • Lepidoptera / genetics*
  • Lepidoptera / metabolism
  • Molecular Sequence Data
  • Proteome / chemistry
  • Proteome / genetics*
  • Proteome / metabolism
  • Sequence Alignment


  • Egg Proteins
  • Insect Proteins
  • Proteome
  • chorion proteins