A simple base-mediated amidation of aldehydes with azides

Chem Commun (Camb). 2013 Feb 11;49(12):1193-5. doi: 10.1039/c2cc37289d.


A practical and efficient amidation reaction involving aromatic aldehydes and various azides under mild conditions is described. A broad spectrum of functional groups was tolerated, and the amides were synthesized in moderate to excellent yields, presenting an attractive alternative to the currently available synthetic methods.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Amides / chemical synthesis
  • Amides / chemistry
  • Azides / chemistry*
  • Cycloaddition Reaction


  • Aldehydes
  • Amides
  • Azides