Prophylactic effect of coconut water (Cocos nucifera L.) on ethylene glycol induced nephrocalcinosis in male wistar rat

Int Braz J Urol. 2013 Jan-Feb;39(1):108-17. doi: 10.1590/S1677-5538.IBJU.2013.01.14.


Purpose: Many medicinal plants have been employed during ages to treat urinary stones though the rationale behind their use is not well established. Thus, the present study was proposed to evaluate the effect of coconut water as a prophylactic agent in experimentally induced nephrolithiasis in a rat model.

Materials and methods: The male Wistar rats were divided randomly into three groups. Animals of group I (control) were fed standard rat diet. In group II, the animals were administrated 0.75% ethylene glycol in drinking water for the induction of nephrolithiasis. Group III animals were administrated coconut water in addition to ethylene glycol. All the treatments were continued for a total duration of seven weeks.

Results and conclusion: Treatment with coconut water inhibited crystal deposition in renal tissue as well as reduced the number of crystals in urine. Furthermore, coconut water also protected against impaired renal function and development of oxidative stress in the kidneys. The results indicate that coconut water could be a potential candidate for phytotherapy against urolithiasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cocos*
  • Creatinine / blood
  • Ethylene Glycol
  • Kidney / drug effects
  • Male
  • Nephrocalcinosis / chemically induced
  • Nephrocalcinosis / drug therapy*
  • Nephrocalcinosis / prevention & control
  • Phytotherapy*
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Real-Time Polymerase Chain Reaction
  • Treatment Outcome
  • Urea / blood
  • Urolithiasis / drug therapy
  • Urolithiasis / prevention & control
  • Water


  • Water
  • Urea
  • Creatinine
  • Ethylene Glycol