Ensuring comprehensive assessment of urinary problems in prostate cancer through patient-physician concordance

Urol Oncol. 2014 Jan;32(1):26.e25-31. doi: 10.1016/j.urolonc.2012.09.006. Epub 2013 Mar 21.


Objectives: To examine the concordance between clinicians and men diagnosed with prostate cancer on a clinician-derived pathophysiological classification of the following self-reported urinary complications: storage (irritative), voiding (obstructive), and leakage/incontinence.

Materials and methods: Fourteen urology experts classified 37 urinary function questionnaire items into 3 primary conceptual dimensions (e.g., storage [irritative], voiding [obstructive] and urinary leakage/incontinence) that would best reflect each item's content. In addition, 218 patient participants provided responses to the 37 items. Using classifications by experts to develop the conceptual framework, the structure was tested using confirmatory factor analyses with patient data.

Results: Expert consensus was achieved in the classification of 31 out of 37 items. Using the 3-factor conceptual framework and patient data, the fit indices for the overall correlated factor model suggested an acceptable overall model fit. The analyses of the separate domains showed acceptable fit for the storage/irritative domain and the leaking/incontinence domain. The dimensionality of the voiding/obstructive domain was too difficult to estimate.

Conclusions: Our analysis found items that conceptually and psychometrically support 2 constructs (leaking/incontinence and storage/irritative). The consistency of this support between the groups suggests a clinical relevance that is useful in treating patients. We have conceptual support for a third hypothesis (voiding/obstructive), although there were too few items to assess this psychometrically. Relative motivating factors of bother and urinary complaints were not addressed and remain an unmet need in this field.

Keywords: Health-related quality of life; Patient-reported outcomes; Prostate cancer; Storage (irritative) symptoms; Urinary incontinence; Voiding (obstructive) symptoms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Humans
  • Male
  • Medical Oncology / standards
  • Middle Aged
  • Prostatic Neoplasms / complications*
  • Prostatic Neoplasms / therapy*
  • Quality of Life
  • Surveys and Questionnaires
  • Symptom Assessment
  • Urinary Bladder Neck Obstruction / diagnosis
  • Urinary Bladder Neck Obstruction / etiology*
  • Urinary Incontinence / diagnosis
  • Urinary Incontinence / etiology*
  • Urination Disorders / diagnosis
  • Urination Disorders / etiology*
  • Urology / standards