[The first results of a combined all-Russian study on clinical genetics of multiple sclerosis]

Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(2 Pt 2):6-9.
[Article in Russian]


Multiple sclerosis is a classic multifactorial disease in which etiology interaction of external factors and structural features of a large number of genes plays an important role. Identifying risk factors for multiple sclerosis and creating an integrated model of pathogenesis are urgent tasks of neurology. Revealing true risk factors is possible only in studies with sufficient statistical power, so with a large amount of samples. We conducted the association study of CD40 gene's polymorphisms and multiple sclerosis among residents of the Russian Federation. The results demonstrated the need to combine data from different researchers in clinical studies to increase the power of the study.

Publication types

  • Comparative Study
  • Multicenter Study

MeSH terms

  • Adult
  • Alleles
  • CD40 Antigens / blood
  • CD40 Antigens / genetics*
  • DNA / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Incidence
  • Male
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / epidemiology
  • Multiple Sclerosis / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Retrospective Studies
  • Risk Assessment / methods*
  • Risk Factors
  • Russia / epidemiology


  • CD40 Antigens
  • DNA