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Comment
. 2013 May 9;497(7448):197-8.
doi: 10.1038/nature12100. Epub 2013 May 1.

Physiology: Inflammation links ageing to the brain

Dana Gabuzda, Bruce A Yankner
Comment

Physiology: Inflammation links ageing to the brain

Dana Gabuzda et al. Nature. .
No abstract available

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Conflict of interest statement

Competing interests: the authors declare no competing financial interests

Figures

Figure 1
Figure 1. Hypothalamic inflammation and control of systemic aging
Zhang et al report that inflammation and activation of NF-kappa B in the hypothalamus of the brain (boxed region) control systemic aging in part through a decline in expression and release of gonadotropin-releasing hormone (GnRH). NF-kappa B activation in microglia, as part of an age-related inflammatory response in the brain, results in production of TNFα, which stimulates NF-kappa B signaling and local neurons. In hypothalamic neurons, NF-kappa B signaling results in epigenetic repression of the GnRH gene, leading to reduced GnRH release and multiple physiological changes related to aging. Abbreviations: ROS, reactive oxygen species; LH, luteinizing hormone; FSH, follicle-stimulating hormone. Reprinted by permission from Macmillan Publishers Ltd: Nature, Gabuzda, D. & Yankner, B.A. 497, 197–198 (2013), copyright 2013.
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