Membrane and actin dynamics interplay at lamellipodia leading edge

Curr Opin Cell Biol. 2013 Oct;25(5):565-73. doi: 10.1016/ Epub 2013 Apr 29.


The multimolecular WAVE regulatory (WRC) and Arp2/3 complexes are primarily responsible to generate pushing forces at migratory leading edges by promoting branch elongation of actin filaments. The architectural complexity of these units betrays the necessity to impose a tight control on their activity. This is exerted through temporally coordinated and coincident signals which limit the intensity and duration of this activity. In addition, interactions of the WRC and Arp2/3 complexes with membrane binding and surprisingly membrane trafficking proteins is also emerging, revealing the existence of an 'endocytic wiring system' that spatially restrict branched actin elongation for the execution of polarized functions during cell migration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin-Related Protein 2-3 Complex / metabolism
  • Actins / metabolism
  • Animals
  • Cell Membrane / metabolism*
  • Cell Movement*
  • Humans
  • Pseudopodia / metabolism*


  • Actin-Related Protein 2-3 Complex
  • Actins