RAP1: protector of telomeres, defender against obesity

Cell Rep. 2013 Jun 27;3(6):1757-8. doi: 10.1016/j.celrep.2013.06.011.

Abstract

Telomere dysfunction has previously been linked to metabolic disorders. In this issue of Cell Reports, Martínez et al. (2013) and Yeung et al. (2013) now extend this link, demonstrating that deletion of the telomere binding protein RAP1 leads to obesity and insulin resistance.

Publication types

  • Comment

MeSH terms

  • Animals
  • Body Weight / genetics*
  • Female
  • Humans
  • Male
  • Obesity / genetics*
  • Telomere / metabolism*
  • Telomere-Binding Proteins / genetics*
  • rap1 GTP-Binding Proteins / metabolism*

Substances

  • Telomere-Binding Proteins
  • rap1 GTP-Binding Proteins