Flurazepam hydrochloride, a benzodiazepine hypnotic

Ann Intern Med. 1975 Aug;83(2):237-41. doi: 10.7326/0003-4819-83-2-237.


Flurazepam hydrochloride is a benzodiazepine derivative marketed for use as a hypnotic agent. Flurazepam is more effective than placebo and is as effective as other hypnotic drugs in most short-term controlled studies. In long-term dosage studies, flurazepam's efficacy persists while other hypnotics become ineffective. Flurazepam has relatively minor effects upon rapid eye movement (REM) sleep and does not lead to REM rebound; this may reduce the likelihood of drug dependence. Flurazepam does not cause enzyme induction and probably presents little hazard of abuse or overdosage. The rational use of hypnotic agents depends as much upon the underlying cause of the sleep disorder as upon the choice of a particular drug. When hypnotic therapy is indicated, flurazepam appears to have advantages over other drugs currently available in the United States.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Anti-Anxiety Agents*
  • Blood Circulation / drug effects
  • Central Nervous System / drug effects
  • Chemical Phenomena
  • Chemistry
  • Electroencephalography
  • Enzyme Induction / drug effects
  • Flurazepam* / administration & dosage
  • Flurazepam* / adverse effects
  • Flurazepam* / metabolism
  • Flurazepam* / pharmacology
  • Flurazepam* / poisoning
  • Humans
  • Intelligence / drug effects
  • Motor Skills / drug effects
  • Respiration / drug effects
  • Sleep / drug effects
  • Sleep / physiology
  • Sleep, REM / drug effects
  • Sleep, REM / physiology


  • Anti-Anxiety Agents
  • Flurazepam