Multi-channel deep tissue flowmetry based on temporal diffuse speckle contrast analysis

Opt Express. 2013 Sep 23;21(19):22854-61. doi: 10.1364/OE.21.022854.

Abstract

Recently, diffuse speckle contrast analysis (DSCA) was introduced as a competent modality for deep tissue blood flow measurement, where the speckle contrast is calculated over spatial domain on the CCD image of diffuse reflectance. In this paper, we introduce time-domain DSCA where temporal statistics are used for speckle contrast calculation and results in the same deep tissue flow measurement. This new modality is especially suitable for multi-channel real-time flowmetry, and we demonstrate its performance on human arm during cuff occlusion test. Independent component analysis (ICA) study on multi-channel data shows promising results about underlying physiology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms*
  • Blood Flow Velocity / physiology*
  • Humans
  • Image Interpretation, Computer-Assisted / methods*
  • Nephelometry and Turbidimetry / methods*
  • Rheology / methods*