Navigating the global protein-protein interaction landscape using iRefWeb

Methods Mol Biol. 2014:1091:315-31. doi: 10.1007/978-1-62703-691-7_22.


iRefWeb is a bioinformatics resource that offers access to a large collection of data on protein-protein interactions in over a thousand organisms. This collection is consolidated from 14 major public databases that curate the scientific literature. The collection is enhanced with a range of versatile data filters and search options that categorize various types of protein-protein interactions and protein complexes. Users of iRefWeb are able to retrieve all curated interactions for a given organism or those involving a given protein (or a list of proteins), narrow down their search results based on different supporting evidence, and assess the reliability of these interactions using various criteria. They may also examine all data and annotations related to any publication that described the interaction-detection experiments. iRefWeb is freely available to the research community worldwide at .

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carrier Proteins / metabolism
  • Computational Biology / methods
  • Databases, Protein
  • Molecular Sequence Annotation
  • Protein Binding
  • Protein Interaction Mapping / methods*
  • Protein Interaction Maps*
  • Proteins / genetics
  • Proteins / metabolism*
  • Proteomics / methods
  • Web Browser*


  • Carrier Proteins
  • Proteins