Enantioselective propargylation and allenylation reactions of ketones and imines

Hanna M Wisniewska; Elizabeth R Jarvo

doi:10.1021/jo4019107

Enantioselective propargylation and allenylation reactions of ketones and imines

J Org Chem. 2013 Dec 6;78(23):11629-36. doi: 10.1021/jo4019107. Epub 2013 Nov 23.

Authors

Hanna M Wisniewska¹, Elizabeth R Jarvo

Affiliation

¹ Department of Chemistry, University of California , Irvine, California 92697-2025, United States.

PMID: 24266761
DOI: 10.1021/jo4019107

Abstract

Enantioselective propargylation and allenylation reactions pose an interesting challenge because they require control of regioselectivity as well as enantioselectivity. This review presents recent advances in enantioselective propargylation and allenylation reactions of ketones and imines. In this context, a brief discussion of the possible mechanisms of these transformations and consequences for regioselectivity is provided.