Enantioselective propargylation and allenylation reactions of ketones and imines

J Org Chem. 2013 Dec 6;78(23):11629-36. doi: 10.1021/jo4019107. Epub 2013 Nov 23.

Abstract

Enantioselective propargylation and allenylation reactions pose an interesting challenge because they require control of regioselectivity as well as enantioselectivity. This review presents recent advances in enantioselective propargylation and allenylation reactions of ketones and imines. In this context, a brief discussion of the possible mechanisms of these transformations and consequences for regioselectivity is provided.