Organ-on-a-chip platforms for studying drug delivery systems

Nupura S Bhise; João Ribas; Vijayan Manoharan; Yu Shrike Zhang; Alessandro Polini; Solange Massa; Mehmet R Dokmeci; Ali Khademhosseini

doi:10.1016/j.jconrel.2014.05.004

Organ-on-a-chip platforms for studying drug delivery systems

J Control Release. 2014 Sep 28:190:82-93. doi: 10.1016/j.jconrel.2014.05.004. Epub 2014 May 10.

Authors

Nupura S Bhise¹, João Ribas², Vijayan Manoharan¹, Yu Shrike Zhang¹, Alessandro Polini¹, Solange Massa¹, Mehmet R Dokmeci¹, Ali Khademhosseini³

Affiliations

¹ Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, 02139, USA.
² Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, 02139, USA; Doctoral Programme in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal; Biocant - Biotechnology Innovation Center, 3060-197 Cantanhede, Portugal.
³ Division of Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, 02139, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston 02115, USA; Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia. Electronic address: alik@rics.bwh.harvard.edu.

Abstract

Novel microfluidic tools allow new ways to manufacture and test drug delivery systems. Organ-on-a-chip systems - microscale recapitulations of complex organ functions - promise to improve the drug development pipeline. This review highlights the importance of integrating microfluidic networks with 3D tissue engineered models to create organ-on-a-chip platforms, able to meet the demand of creating robust preclinical screening models. Specific examples are cited to demonstrate the use of these systems for studying the performance of drug delivery vectors and thereby reduce the discrepancies between their performance at preclinical and clinical trials. We also highlight the future directions that need to be pursued by the research community for these proof-of-concept studies to achieve the goal of accelerating clinical translation of drug delivery nanoparticles.

Keywords: Drug delivery; Drug screening; Nanoparticle; Organ-on-a-chip; Toxicity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomimetic Materials*
Drug Carriers
Drug Delivery Systems*
Drug Discovery / instrumentation*
Drug Evaluation, Preclinical / instrumentation*
Drug Evaluation, Preclinical / methods
Microfluidic Analytical Techniques / instrumentation*
Microfluidics
Nanoparticles

Substances

Drug Carriers

Abstract

Publication types

MeSH terms

Substances

Grants and funding