Modulatory effects of curcumin on redox status, mitochondrial function, and caspace-3 expression during atrazin-induced toxicity

J Biochem Mol Toxicol. 2014 Aug;28(8):378-85. doi: 10.1002/jbt.21574. Epub 2014 May 27.


Atrazin is currently the most widely used herbicide in agriculture with lots of adverse effects on human health. Curcumin is a polyphenol known for its antioxidant, anti-inflammatory, and anticancer properties. In the present study, the protective effect of curcumin on atrazin-intoxicated rats is evaluated. Toxicity was induced by oral administration of atrazine (400 mg/kg/day) for 3 weeks. Curcumin at a dose of 400 mg/kg/day was given simultaneously by oral route. Redox status, mitochondrial function, 8-hydroxydeoxyguanosine (8-OHdG) level by immunoassay, and caspace-3 expression by immunohistochemistry were evaluated. Curcumin showed significant cardiac protection with improvement of redox status, mitochondrial function, 8-OHdG level, caspase-3 immunoreactivity, and cardiac muscle degeneration. From this current study, it can be concluded that administration of curcumin improved atrazine-induced cardiotoxicity through its modulatory effect on redox status, mitochondrial function, and caspase-3 expression.

Keywords: Atrazine; Caspase-3; Curcumin; Mitochondrial Function; Oxidant/Antioxidant Status.

MeSH terms

  • Animals
  • Antioxidants / administration & dosage*
  • Atrazine / toxicity
  • Caspase 3 / biosynthesis*
  • Curcumin / administration & dosage*
  • Gene Expression Regulation
  • Humans
  • Lipid Peroxidation / drug effects
  • Male
  • Mitochondria / drug effects
  • Oxidation-Reduction / drug effects
  • Oxidative Stress / drug effects*
  • Rats


  • Antioxidants
  • Caspase 3
  • Curcumin
  • Atrazine