BPA, an energy balance disruptor

Crit Rev Food Sci Nutr. 2015;55(6):769-77. doi: 10.1080/10408398.2012.678421.


Bisphenol A (BPA) is used extensively in the world and is present in a diverse range of manufactured articles including dental resins, polycarbonate plastics, and the inner coating of food cans. It is a high volume chemical, with global production at 3.6 × 10(9) kg per year. BPA was identified as a high priority for assessment of human health risk because it was considered to present greatest potential for human exposure. Most studies of the health effects of BPA have focused on endocrine disruption leading to reproductive toxicity, but it displays additional side effects, including liver damage, disrupted pancreatic β-cell function, thyroid hormone disruption, and obesity-promoting effects. In this article, we reviewed specifically on the effects of BPA in energy balance.

Keywords: Bisphenol A; endocrine disruptor; lipid and glucose homeostasis; obesogens; toxic chemical.

Publication types

  • Review

MeSH terms

  • Animals
  • Benzhydryl Compounds / adverse effects*
  • Endocrine Disruptors / adverse effects*
  • Energy Metabolism / drug effects*
  • Environmental Exposure / adverse effects*
  • Female
  • Humans
  • Male
  • Phenols / adverse effects*
  • Rats
  • Weight Gain / drug effects


  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Phenols
  • bisphenol A