A structural perspective of compensatory evolution

Curr Opin Struct Biol. 2014 Jun;26(100):104-12. doi: 10.1016/j.sbi.2014.05.004. Epub 2014 Jun 28.


The study of molecular evolution is important because it reveals how protein functions emerge and evolve. Recently, several types of studies indicated that substitutions in molecular evolution occur in a compensatory manner, whereby the occurrence of a substitution depends on the amino acid residues at other sites. However, a molecular or structural basis behind the compensation often remains obscure. Here, we review studies on the interface of structural biology and molecular evolution that revealed novel aspects of compensatory evolution. In many cases structural studies benefit from evolutionary data while structural data often add a functional dimension to the study of molecular evolution.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Evolution, Molecular*
  • Humans
  • Protein Engineering
  • Proteins / chemistry*
  • Proteins / genetics
  • Proteins / metabolism*


  • Proteins