[Antidepressants-SSRIs in pregnancy and risk of major malformations: treat or not to treat]

Recenti Prog Med. 2014 Jun;105(6):254-61. doi: 10.1701/1543.16855.
[Article in Italian]


Considering teratogenic risk, recent data suggest that selective serotonin reuptake inhibitors (SSRIs) can be prescribed during pregnancy, even though some SSRIs are to be considered as a second choice. In any case, antidepressive treatment during pregnancy must be carefully tailored to the pregnant woman, considering absolute risk/benefit ratio of SSRIs, but also availability of other effective treatments, as well as woman's preferences.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Abnormalities, Drug-Induced / prevention & control
  • Adult
  • Antidepressive Agents, Second-Generation / administration & dosage
  • Antidepressive Agents, Second-Generation / adverse effects
  • Antidepressive Agents, Second-Generation / therapeutic use*
  • Depression / drug therapy*
  • Depression / epidemiology
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Italy / epidemiology
  • Pregnancy
  • Prenatal Exposure Delayed Effects / prevention & control
  • Prevalence
  • Risk Assessment
  • Selective Serotonin Reuptake Inhibitors / administration & dosage
  • Selective Serotonin Reuptake Inhibitors / adverse effects
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*
  • Treatment Outcome


  • Antidepressive Agents, Second-Generation
  • Serotonin Uptake Inhibitors