Neutralizing the HIV reservoir

Cell. 2014 Aug 28;158(5):971-972. doi: 10.1016/j.cell.2014.08.010.


Halper-Stromberg et al. use a humanized mouse model to demonstrate that broadly neutralizing antibodies, when administered with a combination of HIV latency activators, can reduce persistent HIV reservoirs, as measured by plasma virus rebound. Their results support the use of broadly neutralizing antibodies in HIV-reservoir-purging strategies.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antibodies, Neutralizing / administration & dosage*
  • HIV Infections / immunology*
  • HIV-1 / drug effects*
  • Humans
  • Transcription, Genetic / drug effects*
  • Virus Latency / drug effects*


  • Antibodies, Neutralizing