Ensuring continued progress in biomarkers for amyotrophic lateral sclerosis

Muscle Nerve. 2015 Jan;51(1):14-8. doi: 10.1002/mus.24470. Epub 2014 Nov 24.


Multiple candidate biomarkers for amyotrophic lateral sclerosis (ALS) have emerged across a range of platforms. Replication of results, however, has been absent in all but a few cases, and the range of control samples has been limited. If progress toward clinical translation is to continue, the specific biomarker needs of ALS, which differ from those of other neurodegenerative disorders, as well as the challenges inherent to longitudinal ALS biomarker cohorts, must be understood. Appropriate application of multimodal approaches, international collaboration, presymptomatic studies, and biomarker integration into future therapeutic trials are among the essential priorities going forward.

Keywords: biomarker; motor neuron disease; neurochemistry; neuroimaging; trial.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Amyotrophic Lateral Sclerosis / diagnosis
  • Amyotrophic Lateral Sclerosis / metabolism*
  • Biomarkers / metabolism*
  • Humans


  • Biomarkers