Evaluation of platelet distribution width and mean platelet volume in patients with carotid artery stenosis

Angiology. 2015 Apr;66(4):375-8. doi: 10.1177/0003319714548682. Epub 2014 Oct 13.


Platelets contribute to the pathogenesis of atherosclerosis. Platelet activation has been linked with increased mean platelet volume (MPV) and platelet distribution width (PDW). We investigated the association between PDW, MPW, and the degree of carotid artery stenosis (CS). Patients (n = 229) were divided into 3 groups according to the North American Symptomatic Carotid Endarterectomy Trial criteria. Demographic and clinical features were collected retrospectively. Correlation analysis showed a positive association between PDW and the degree of CS. However, there was no significant correlation between CS and MPV. Moreover, we observed that PDW and low-density lipoprotein cholesterol were independent predictors of the degree of CS. This study showed that PDW, not MPV, is related to the degree of CS. Platelet distribution width could be a useful biomarker for CS. Whether targeting PDW will be of clinical benefit remains to be established.

Keywords: carotid artery stenosis; mean platelet volume; platelet distribution width.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Platelets / pathology*
  • Carotid Stenosis / blood*
  • Carotid Stenosis / diagnostic imaging
  • Cell Size
  • Disease Progression
  • Female
  • Humans
  • Male
  • Mean Platelet Volume*
  • Middle Aged
  • Multidetector Computed Tomography
  • Platelet Activation*
  • Predictive Value of Tests
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Young Adult