Anti-CD45RA antibodies increase the proliferation of mouse T cells to phytohemagglutinin through the interleukin 2/interleukin 2 receptor pathway

Eur J Immunol. 1989 Nov;19(11):2005-10. doi: 10.1002/eji.1830191106.


We have studied the effect of anti-CD45RA monoclonal antibodies on the proliferation of murine spleen T cells activated with phytohemagglutinin. Antibodies act on both CD8 and CD4 subsets of T cells. They seem to replace a signal normally delivered by accessory cells which would act through the interleukin 2/interleukin 2 receptor pathway.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antigen-Antibody Reactions
  • Antigen-Presenting Cells / immunology
  • Antigens, Differentiation / physiology*
  • Histocompatibility Antigens / physiology
  • Leukocyte Common Antigens
  • Lymphocyte Activation*
  • Mice
  • Phytohemagglutinins / pharmacology
  • Receptors, Interleukin-2 / physiology*
  • T-Lymphocytes / cytology
  • T-Lymphocytes / physiology*


  • Antibodies, Monoclonal
  • Antigens, Differentiation
  • Histocompatibility Antigens
  • Phytohemagglutinins
  • Receptors, Interleukin-2
  • Leukocyte Common Antigens