Abstract
We have studied the effect of anti-CD45RA monoclonal antibodies on the proliferation of murine spleen T cells activated with phytohemagglutinin. Antibodies act on both CD8 and CD4 subsets of T cells. They seem to replace a signal normally delivered by accessory cells which would act through the interleukin 2/interleukin 2 receptor pathway.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology
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Antigen-Antibody Reactions
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Antigen-Presenting Cells / immunology
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Antigens, Differentiation / physiology*
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Histocompatibility Antigens / physiology
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Leukocyte Common Antigens
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Lymphocyte Activation*
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Mice
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Phytohemagglutinins / pharmacology
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Receptors, Interleukin-2 / physiology*
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T-Lymphocytes / cytology
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T-Lymphocytes / physiology*
Substances
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Antibodies, Monoclonal
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Antigens, Differentiation
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Histocompatibility Antigens
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Phytohemagglutinins
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Receptors, Interleukin-2
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Leukocyte Common Antigens